The combination of bupropion and naltrexone in Contrave has a synergistic effect. Clinical studies have shown that Contrave can effectively help patients lose weight and improve some obesity-related metabolic indicators. For patients with obesity and comorbid depression or other psychological problems, Contrave may be a more suitable choice because it can not only help with weight loss but also improve mental state.

However, like other drugs, Contrave also has side effects. The common side effects include nausea, vomiting, headache, and dry mouth. In addition, because bupropion has certain effects on the nervous system, patients may also experience symptoms such as dizziness and insomnia.

It should be noted that Contrave is contraindicated in some patients, such as those with a history of seizures, liver and kidney function impairment, and opioid dependence. Therefore, before using Contrave, it is necessary to inform the doctor of the patient's medical history and conduct a comprehensive evaluation.

Overall, Contrave provides a new combination therapy option for the treatment of obesity. But its use needs to be carefully evaluated and monitored by a doctor to ensure the safety and effectiveness of treatment.